在一篇發表在《細胞》期刊的研究顯示📜，負責修復受損基因的SIRT6對延長壽命非常重要。人體細胞中無時無刻都有DNA受到損害，當細胞累積大量 DNA 損傷而老化時，其修復速度就會減慢；隨著年紀增長，DNA 會越來越容易斷裂，出現 DNA 雙股斷裂（double-strand break）。基因組的變異及不穩定 - 是患上癌症及加速老化的標誌之一。過往實驗發現，較長壽的物種SIRT6之活性較強。
你的逆齡鎖匙: NMN與 NAD+
The Sirtuin Story Unfolds: Why We Age and Why We Don't Have To
It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been told to believe about aging is not true? What if we could control over how long we live? With years of research, scientists have revealed an incredible breakthroughs - the key to slow down, or even reverse aging lies in the ‘Sirtuin’ (SIRT) longevity genes🧬. There are 7 types of SIRT in our body, which is required for DNA repair, genome stability, cell cycle and inflammatory response. However, SIRT is keeping silent unless it gets activated, improving health and banishing diseases of old age. A study published in the journal Cell discovered that SIRT6 is crucial for extending lifespan because of its role in recruiting enzymes that repair broken DNA📜. Replication errors and DNA damage occur in human cells all the time. As we grow older, DNA becomes more prone to breakage. DNA mutation and instability is one of the hallmarks of cancer and aging. Previous experiments have found that species with a more active SIRT6 live longer.
Rewinding your biological clock: NMN and NAD+
If the longevity gene SIRT were a car, NMN would be the fuel that allowed it to run. In our body, NAD+ is an important coenzyme. It involved in numberous key metabolic pathways. More importantly, it is an essential substrates for DNA repair enzyme (PARP) and the key to determine SIRT activity🧬. Aging is linked to a decrease in NAD+ levels📉, however, we cannot directly absorb NAD+ through oral intake due to its bulky size. Contrarily, NMN, the precursor of NAD+, can easily penetrate the cell membrane. Two NMNs combine to form one NAD+. Research showed that NMN only takes 10-30 minutes to get into body tissues, significantly increasing NAD+ content and restoring youth. Although NMN is found in a variety of foods including vegetables and fruits, the amount is too subtle to create a repairing effect. So if you want to effectively boost your NAD+ level, taking NMN supplements is the way to go - more straightforward!
In the near future, we may not just be able to feel younger, but actually become younger…